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Risk Factors of Cardiovascular Disorders - Diseases

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Diabetes: Patients with type 2 diabetes mellitus who are more frequent silent myocardial ischemia by ambulatory ECG recording had been found to have angiographically more extensive coronary artery disease (Farag et. al. 2014).

Adenocarcinoma of Gall bladder: Metastatic spread to heart from carcinoma of gallbladder is very rare. Should a patient be suspected of or an operated case of gallbladder carcinoma present with symptoms of congestive heart failure and massive pericardial effusion, cardiac metastasis should be considered (Gunjiganvi et. al., 2013).

Chronic Kidney Disease: Structural heart disease is highly prevalent in patients with chronic kidney disease requiring dialysis. More than 80% of patients with end-stage renal disease (ESRD) are reported to have cardiovascular disease (Chawla et. al. 2014).

Trypanosoma cruzi infection: the principal findings are prolonged fever, lymph node enlargement, hepatomegaly, splenomegaly, subcutaneous edema, signs of portal of entry of the parasite and meningoencephalitis and/or myocarditis in severe cases (Rassi et. al. 2010).

Obesity: Along with inactivity the persons with obesity and overweight are prone to diabetes and cardiovascular disorders. Expanded and inflamed visceral adipose tissue releases a wide array of molecules potentially involved in the development of insulin resistance and atherosclerosis, including free fatty acids, interleukin-6, tumor necrosis factor, monocyte chemotactic protein 1 (CC chemokine ligand 2), and other pro-inflammatory cytokines. These cytokines may derive from adipocytes themselves, infiltrating macrophages, or both (Targher et. al., 2010).

Long QT Syndrome and Brugada Syndrome: These are most common cardiac arrythmogenic disease associated with sodium channelopathy (Miller et. al. 2014). The expression of β-subunits together with α subunits enhances the Na+ current and modifies the channel activities. The interactions of the cardiac sodium channel with other proteins may facilitate the channel activity and membrane expression of the channel.

Fabry's disease is an X-linked lysosomal storage disorder caused by abnormalities in the GLA gene, which leads to a deficiency in α-galactosidase A. The abnormal accumulation of glycosphingolipids, primarily globotriaosylceramide, manifests as serious and progressive impairment of renal and cardiac functions (El-Abassi et. al. 2014).

Cardiovascular Disorders - Index

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